A turbulent love story taking place in a hospital that specializes in skincare Their romantic relationship occurred because of an accident when Win, a handsome and chic young man, has to fall in love with a sly sassy girl like Beauty, a young girl with a degree in online game streaming. Beauty also has a friend name Minnie. Along with this cute young couple, there is also a rejuvenating couple when a young man like James, a doctor's assistant, has to take care of Teenoi, a high school boy who is the young brother of Beauty.

Follow up to Skinship Season 1. After Win and Beauty's break up, to help him move on, Win's friends Minnie, Teenoi, and James try to find him a new love. At the same time, Minnie waits for a love for her to appear.