Season 0 of Best of Luck Nikki premiered on null.

Season 1 revolves around a studious Dolly and her crush on Ritesh, and she has adventures with her best friend Parminder, nicknamed Pam. Sunny frequently challenges the nosy neighbour Roli Aunty, while Rohan and his best friend Popi work on their band and try to impress girls. Himani has just returned to work after a maternity break, and Avatar is busy with his electronics business.

Season 2 shows Dolly dating her childhood nemesis Rahul, and Pam starts dating Rahul's best friend Jatin. Sunny has also started dating and tries to impress some of his classmates while maintaining his constant pranks. Rohan and Popi prepare to begin college, while Himani and Avatar struggle with a growing Nikki and their work

Season 3 follows all of the children who have now grown up, and Himani who is pregnant again with a boy, whom they later name Bobby. Avatar is busy with work, while Sunny still indulges in pranks and experiences typical high-school problems. Dolly is now dating the basketball captain Ayaan, and Rohan experiments with his career choices at college. Nikki enrolls in a playschool, and they all help with raising Bobby.

Season 4 is the final of the series. All the characters had aged and Himani became pregnant again. Avatar struggles to arrange their older house and keeps the family in a one-room flat while waiting. Rohan and Popi move to their own flat. Rohan has entered culinary school, while Dolly begins interning with her father and pursues journalism. She starts dating her father's assistant Avishkaar, while Sunny starts dating Roli Aunty's granddaughter Riya.