Season 1 of Cuarto Milenio premiered on 2005-11-13.

Season 2 of Cuarto Milenio premiered on 2006-09-10.

Season 3 of Cuarto Milenio premiered on 2007-09-09.

Season 4 of Cuarto Milenio premiered on 2008-09-07.

Season 5 of Cuarto Milenio premiered on 2009-09-28.

Season 6 of Cuarto Milenio premiered on 2010-09-19.

Season 7 of Cuarto Milenio premiered on 2011-09-19.

Season 8 of Cuarto Milenio premiered on 2012-09-09.

Season 9 of Cuarto Milenio premiered on 2013-09-08.

Season 10 of Cuarto Milenio premiered on 2014-09-07.

Season 11 of Cuarto Milenio premiered on 2015-09-06.

Season 12 of Cuarto Milenio premiered on 2016-09-04.

Season 13 of Cuarto Milenio premiered on 2017-09-03.

Season 14 of Cuarto Milenio premiered on 2018-09-02.

Season 15 of Cuarto Milenio premiered on 2019-09-15.

Season 16 of Cuarto Milenio premiered on 2021-01-10.

Season 17 of Cuarto Milenio premiered on 2021-09-05.

Season 18 of Cuarto Milenio premiered on 2022-09-11.

Season 19 of Cuarto Milenio premiered on 2023-09-10.

Season 20 of Cuarto Milenio premiered on 2024-09-08.

Season 21 of Cuarto Milenio premiered on 2025-09-07.