Naoko, a career woman from Tokyo marries Sosuke, son of a distinguished Japanese inn located in Kanazawa. However, the inn's madam – Sosuke's mother – rejected her son's marriage to an "outsider". One day, Sosuke vanishes, leaving behind him a large debt. To make things worse, Naoko's company goes out of business. In effort to pay off Sosuke's debts, Naoko tells the madam that she wants to work at the inn.

Season 2 of Mother-in-Law VS. Daughter-in-Law premiered on 2011-10-31.

Season 3 of Mother-in-Law VS. Daughter-in-Law premiered on 2014-01-06.

Season 4 of Mother-in-Law VS. Daughter-in-Law premiered on 2015-01-05.